The invention relates to a process for preparing a liquid pharmaceutical formulation containing a complex of macrocyclic chelate with a lanthanide and a mol/mol amount of free macrocyclic chelate of between 0.002% and 0.4%, said process comprising the following successive steps:b) preparation of a liquid pharmaceutical composition containing the complex of macrocyclic chelate with a lanthanide, free macrocyclic chelate that is not under the form of an excipient X[X,L] in which L is the macrocyclic chelate and X and X are a metal ion, in particular chosen independently from calcium, sodium, zinc and magnesium, and/or free lanthanide,said step b) consisting in the preparation of a solid complex [chelate-lanthanide] and in the dissolution of the said complex in water c) measurement in the pharmaceutical formulation obtained in step b) of the concentration of free macrocyclic chelate Cch 1 or of free lanthanide Clan 1d) adjustment of Cch 1 and/or of Clan 1 by adding to the formulation obtained in step b) :- if Clan 1 > 0 and/or Cch 1 < Ct ch 1, free macrocyclic chelate,- if Clan 1 = 0 and Cch 1 > Ct ch 1, free lanthanide,so as to obtain Cch 1 = Ct ch 1 and Clan 1 = 0 wherein Ct ch 1 is the target concentration of the free macrocyclic chelate in the final liquid pharmaceutical formulation and is selected in the range of between 0.002 % and 0.4 % mol/mol,wherein the amount of free macrocyclic chelate in the final liquid pharmaceutical formulation corresponds to the proportion of free macrocyclic chelate relative to the amount of complexed macrocyclic chelate in the final liquid pharmaceutical formulation.
