An animal temperature regulation garment (100) includes multiple pouches (130, 132, 134) with temperature control packets (150, 152) which allow an animal (200), such as a pet dog, to play or exercise comfortably in hot or cold climates. When it would otherwise be too hot for outdoor activity, the animal temperature regulation garment may be worn with cooling packs in the pouches, allowing the animal to engage in outdoor activity while reducing the likelihood of heat stroke or other heat-related illness. In the cold, the cooling packs in the temperature regulation garment may be replaced with heating packs.