서울대학교산학협력단;정종평;주식회사 나이벡;SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION;SUH, Jin Sook;NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION. CO. LTD.;박윤정;PARK, Yoon-Jeong;LEE, Jue-Yeon;이주연;CHUNG, Chong-Pyoung
发明人:
CHUNG, Chong-Pyoung,정종평,PARK, Yoon-Jeong,박윤정,LEE, Jue-Yeon,이주연,SUH, Jin Sook,서진숙
申请号：
KRKR2011/002990
公开号：
WO2012/033272A1
申请日:
2011.04.25
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
The present invention relates to a novel human-derived cell-permeable bioactive peptide conjugate, and to the use thereof, and more particularly, to a human-derived cell-permeable bioactive peptide conjugate, and to a pharmaceutical composition for treatment containing same, wherein a cell permeable peptide chemically binds to a bioactivity-inducing sequence selected from the group consisting of a bone differentiation inducing sequence, a bone regeneration inducing sequence, and an anticancer sequence, and introduces, into cells, an important domain of the proteins of impermeable cells having bioactivity, so as to permeate the target cells and function as a peptide treatment agent. According to the present invention, cationic cell permeable peptides derived from human bone morphogenetic protein-4 have no toxicity and immunogenicity and thus exhibit high stability as compared to viral peptide delivery vehicles, and can transport cell impermeable material into cells and into an organism without any damage to the cell or material, thereby significantly increasing target gene expression. Also, the peptide can be applied to clinical use without having to undergo a large number of processes and can be mass-produced, such that it can be useful in the development of a drug delivery systems and treatment technologies using said peptide.La présente invention concerne un nouveau conjugué de peptide bioactif perméable aux cellules dérivé d'humain, et son utilisation, et plus particulièrement, un conjugué de peptide bioactif perméable aux cellules dérivé d'humain, une composition pharmaceutique de traitement le contenant, où un peptide perméable aux cellules se lie chimiquement à une séquence induisant une bioactivité choisie dans le groupe constitué par une séquence induisant une différenciation osseuse, une séquence induisant une régénération osseuse et une séquence anticancéreuse, et introduit, dans des cellules, un important domaine des protéines de cellules imperméables pré
