SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION;NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO., LTD.
发明人:
CHUNG, CHONG-PYOUNG,PARK, YOON-JEONG,LEE, JUE-YEON,SUH, JIN SOOK
申请号：
EP11823705
公开号：
EP2615105A4
申请日:
2011.04.25
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
The present invention relates to a novel human-derived cell permeable peptide-bioactive peptide conjugate and the use thereof, and more particularly, to human-derived cell permeable peptide-bioactive peptide conjugate capable of directly permeate into a target cell to function as a peptide therapeutics by chemically binding cell permeable peptide to a bioactivity inducing sequences selected from a group consisting of a bone differentiation inducing sequence, a bone regeneration inducting sequence, and an anti-inflammation functional sequence to thereby directly introduce an important domain of an impermeable intracellular protein having a bioactivity into cells, and to a pharmaceutical composition for treatment containing the same. According to the present invention, cationic cell permeable peptides derived from human bone morphogenetic protein-4 have no toxicity and immuno-genicity and thus exhibit high stability as compared to viral peptide delivery vehicles, and can transport cell impermeable material into cells and into an organism without any damage to cell or material, thereby significantly increasing target gene expression. In addition, the peptide may be applied to clinical use without having to undergo a large number of processes and mass-produced, such that the present invention may be useful in the development pf a drug delivery system and treatment technologies using said peptide.
