Kang, Heun-Soo,Park, So-Hyun,Song, Yeong Wook,Shin, Ki Chul,Lee, Eun Young,Lee, Eun Bong,Park, Young Woo,Park, Bum-Chan,Lee, Dong Hee,Kim, Dong Jin,Yun, Seon Ha,Lee, Ke Se,Lee, Hyun Ju,Kim, Kyung Jin
申请号：
AU2014269287
公开号：
AU2014269287A1
申请日:
2014.05.22
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
The present invention relates to a TNF-α (tumor necrosis factor-alpha)/CXCL-10 (C-X-C motif chemokine 10) double targeting antibody based on the IgG format. Specifically, it was verified that an antibody, in which scFv having a heavy chain variable region and a light chain variable region of the CXCL10 specific antibody binds to the C-terminus of the heavy chain variable region of the TNF-α specific antibody, is a bispecific antibody that effectively binds to both TNF-α and CXCL10, and thus the antibody can be useful as a double targeting antibody capable of identifying TNF-α/CXCL10. A composition of the present invention comprises a TNF-α/CXCL-10 double targeting antibody which effectively binds to both TNF-α and CXCL10. The double targeting antibody of the present invention has excellent TNF-α inhibitory activity and osteoclast differentiation inhibitory activity compared with the TNF-α or CXCL10 single targeting antibody. The composition of the present invention can be used in preventing or treating immunological disease.
