KANG, HEUN-SOO,PARK, SO-HYUN,SONG, YEONG WOOK,SHIN, KI CHUL,LEE, EUN YOUNG,LEE, EUN BONG,PARK, YOUNG WOO,PARK, BUM-CHAN,LEE, DONG HEE,KIM, DONG JIN,YUN, SEON HA,LEE, KE SE,LEE, HYUN JU,KIM, KYUNG JIN
申请号：
EP14801159
公开号：
EP3000827A4
申请日:
2014.05.22
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The present invention relates to a TNF-± (tumor necrosis factor-alpha)/CXCL-10 (C-X-C motif chemokine 10) double targeting antibody based on the IgG format. Specifically, it was verified that an antibody, in which scFv having a heavy chain variable domain and a light chain variable domain of the CXCL10 specific antibody links to the C-terminus of the heavy chain constant domain of the TNF-± specific antibody, is a bispecific antibody that effectively binds to both TNF-± and CXCL10, and thus the antibody can be useful as a double targeting antibody capable of identifying TNF-±/CXCL10. A composition of the present invention comprises a TNF-±/CXCL-10 double targeting antibody which effectively binds to both TNF-± and CXCL10. The double targeting antibody of the present invention has excellent TNF-± inhibitory activity and osteoclast differentiation inhibitory activity compared with the TNF-± or CXCL10 single targeting antibody. The composition of the present invention can be used in preventing or treating immunological disease.
