KANG, HEUN-SOO,PARK, SO-HYUN,SONG, YEONG WOOK,SHIN, KI CHUL,LEE, EUN YOUNG,LEE, EUN BONG,PARK, YOUNG WOO,PARK, BUM-CHAN,LEE, DONG HEE,KIM, DONG JIN,YUN, SEON HA,LEE, KE SE,LEE, HYUN JU,KIM, KYUNG JIN
申请号：
PH12015502601
公开号：
PH12015502601A1
申请日:
2015.11.23
申请国别(地区):
PH
年份:
2016
代理人:
摘要：
The present invention relates to a TNF-a (tumor necrosis factor-alpha)/CXCL-10 (C-X-C motif chemokine 10) double targeting antibody based on the IgG format. Specifically, it was verified that an antibody, in which scFv having a heavy chain variable region and a light chain variable region of the CXCL10 specific antibody binds to the C-terminus of the heavy chain variable region of the TNF-a specific antibody, is a bispecific antibody that effectively binds to both TNF-a and CXCL10, and thus the antibody can be useful as a double targeting antibody capable of identifying TNF-a/CXCL10. A composition of the present invention comprises a TNF-a/CXCL-10 double targeting antibody which effectively binds to both TNF-a and CXCL10. The double targeting antibody of the present invention has excellent TNF-a inhibitory activity and osteoclast differentiation inhibitory activity compared with the TNF-a or CXCL10 single targeting antibody. The composition of the present invention can be used in preventing or treating immunological disease.
