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NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE CONTAINING PHENYL GROUP AS SUBSTITUTE, HAVING SULPHONIC ACID ESTER STRUCTURE OR SULPHONIC ACID AMIDE STRUCTURE, AND HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY
专利权人:
LTD.;SANTEN FARMAS'JUTIKAL KO.;SANTEN FARMASJUTIKAL KO.
发明人:
MATsUDA Mamoru (JP),МАЦУДА Мамору (JP),MORI Tosijuki (JP),МОРИ Тосиюки (JP),NAGATsUKA Masato (JP),НАГАЦУКА Масато (JP),KOBAJaSI Satiko (JP),КОБАЯСИ Сатико (JP),KATO Masatomo (JP),КАТО Масатомо (JP),TA,MATSUDA MAMORU,МАЦУДА Мамору,MORI TOSIJUKI,МОРИ Тосиюки,NAGATSUKA MASATO,НАГАЦУКА Масато,KOBAJASI SATIKO,КОБАЯСИ Сатико,KATO MASATOMO,КАТО Масатомо,TAKAI MIVA,ТАКАИ Мива
申请号:
RU2009149185/04
公开号:
RU0002498980C2
申请日:
2008.05.29
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to compounds of general formula (1) or salts thereof, where in formula (1) R1 is a lower C1-C6alkyl group, a lower C3-C6cycloalkyl group, a phenyl group, a heterocyclic group, which relates to a residue formed by removing a hydrogen atom from a saturated or unsaturated monocyclic heterocyclic ring containing one, two or three heteroatoms in the ring, selected from a nitrogen atom, an oxygen atom and a sulphur atom, or a phenyl(C1-C6alkyl) group; in cases when R1 is a lower C1-C6alkyl group, that lower C1-C6alkyl group can have, as substitute(s), one, two or three groups selected from a halogen atom, a heterocyclic group which relates to a residue formed by removing a hydrogen atom from a saturated monocyclic heterocyclic ring containing one or two heteroatoms in the ring, selected from a nitrogen atom and an oxygen atom, a carboxyl group, a lower C1-C6alkoxycarbonyl group, a lower C1-C6alkylamino group, a lower C1-C6alkylamino group, substituted with a lower C1-C6alkylamino group, a lower C1-C6alkylamino group, substituted with a phenyl group; in cases when R1 is a phenyl group, a heterocyclic group which relates to a residue formed by removing a hydrogen atom from a saturated or unsaturated monocyclic heterocyclic ring containing one, two or three heteroatoms in the ring, selected from a nitrogen atom, an oxygen atom or a sulphur atom, or a phenyl(C1-C6alkyl) group, that phenyl, heterocyclic or phenyl(C1-C6alkyl) group can contain, as substitute(s), one, two or three groups selected from a halogen atom, a lower C1-C6alkyl group, a hydroxyl group or a lower C1-C6alkoxy group; R2 is a hydrogen atom or a lower C1-C6alkyl group; R3 is a hydrogen atom or a lower C1-C6alkyl group; R4 and R5 can be identical or different and are a hydrogen atom or a lower C1-C6alkyl group; R6 is a hydrogen atom or a lower C1-C6alkyl group; R7 is a phenyl group or a heterocyclic group which relates to a residue formed by removing a hydrogen at
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