Gibson, Iain Ronald,Skakle, Janet Mabel Scott,Conway, Jordan Christopher,Annaz, Basil
申请号:
AU2011268762
公开号:
AU2011268762B2
申请日:
2011.06.22
申请国别(地区):
AU
年份:
2015
代理人:
摘要:
The bone graft system comprises a solid inorganic component, which is bone graft material, and a hydrogel. The hydrogel contains >;2ppm of silicon ions, calculated as parts by weight of Si per million of the aqueous component of the hydrogel. Preferably, the solid inorganic component comprises hydroxyapatite or a silicon-containing hydroxyapatite, and may be a silicon- containing hydroxyapatite having a Ca/P ratio in the range 2.05 to 2.55 and a Ca/(P + Si) molar ratio less than 1.66. Bone healing is promoted by delivery of silicon ion release from the hydrogel and by the solid inorganic component stimulating cell behaviour.