ALBERATI, DANIELA,ALVAREZ SANCHEZ, RUBEN,BLEICHER, KONRAD,FLOHR, ALEXANDER,ZBINDEN, KATRIN GROEBKE,KOERNER, MATTHIAS,KUHN, BERND,PETERS, JENS-UWE,RUDOLPH, MARKUS
申请号：
PE0003652012
公开号：
PE14382012A1
申请日:
2010.09.21
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Refers to a compound imidazopiridina Derivative of formula (i) where a is n or C (r6) r1 is H, alkyl or lower than fluoroalquilo R2 is Halogen, C (o) C (o) or nr7r8 or9 R3 is H, alkyl alkoxy Lower, Lower, Lower alkoxy fluoro among other Lower alkyl R4 is H, fluoroalqu ILO Lower, Lower alkoxy,Among others, R5 is aryl or heteroaryl optionally substituted by alkyl substituents selected from 1 to 3 Lower, Lower alkoxy, among others R6 h, halogen, CN, cycloalkyl, among others R7 and R8 are independently h, Lower alkyl, cycloalkyl, fluoroalquilo Lower, ent Re R9 is H,Lower alkyl or lower fluoroalquilo compounds are preferred: (2 - phenyl imidazo [1,2-a] pyridin - 7 - yl) - amide acid 4 - chlorine - 2 - methyl - 2 - 3 - 4 - pyrazole carboxylic acid dimetilamida - 3 - [(2 - phenyl imidazo [1,2-a] pyridin - 7 - il]) - amide acid 2-methyl - 2H - pyrazole - 3.4 - dicarboxilico 2 - phenyl - (imidazo [1,2-a] P Iridin - 7 - yl) - amide acid, 2 - methyl - 4 - (Morpholine - 4 - carbonyl) - 2H - pyrazole carboxylic acid - 3 -, among others.Also refers to a composition. This Compound is an inhibitor of pde10a Enzyme, being useful in the treatment of schizophrenia, Parkinsons disease, multiple sclerosis, strokeSE REFIERE A UN COMPUESTO DERIVADO DE IMIDAZOPIRIDINA DE FORMULA (I) DONDE: A ES N O C(R6) R1 ES H, ALQUILO INFERIOR O FLUOROALQUILO INFERIOR R2 ES HALOGENO, C(O)NR7R8 O C(O)OR9 R3 ES H, ALQUILO INFERIOR, ALCOXI INFERIOR, FLUORO-ALCOXI INFERIOR, ENTRE OTROS R4 ES H, ALQUILO INFERIOR, FLUOROALQUILO INFERIOR, ALCOXI INFERIOR, ENTRE OTROS R5 ES ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDO POR 1 A 3 SUSTITUYENTES SELECCIONADOS ENTRE ALQUILO INFERIOR, ALCOXI INFERIOR, ENTRE OTROS R6 ES H, HALOGENO, CN, CICLOALQUILO, ENTRE OTROS R7 Y R8 SON INDEPENDIENTEMENTE H, ALQUILO INFERIOR, CICLOALQUILO, FLUOROALQUILO INFERIOR, ENTRE OTROS R9 ES H, ALQUILO INFERIOR O FLUOROALQUILO INFERIOR SON COMPUESTOS PREFERIDOS: (2-FENIL-IMIDAZO[1,2-a]PIRIDIN-7-IL)-AMIDA DEL ACIDO 4-CLORO-2-METIL-2H-PIRAZOL-
