ALDERBIO HOLDINGS LLC;BRISTOL-MYERS SQUIBB COMPANY
发明人:
GARCIA-MARTINEZ, LEON,JENSEN, ANNE ELISABETH CARVALHO,OLSON, KATIE,DUTZAR, BEN,LATHAM, JOHN,KOVACEVICH, BRIAN,SMITH, JEFFREY T.L.,LITTON, MARK,SCHATZMAN, RANDALL
申请号：
EP10833908
公开号：
EP2504031A4
申请日:
2010.11.24
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
The present invention is directed to therapeutic methods and compositions, especially subcutaneous and intravenous composition using antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat cachexia, fever, weakness and/or fatigue in a patient in need thereof. In preferred embodiments, the anti-IL-6 antibodies will be humanized and/or will be aglycosylated. Also, in preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level. In another preferred embodiment, the patient's survivability or quality of life will preferably be improved.
