Smith, Jeffrey T. L.,Schatzman, Randall C.,Litton, Mark,Latham, John
申请号：
AU2009323008
公开号：
AU2009323008B2
申请日:
2009.11.24
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
The present invention is directed to therapeutic methods using antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat cachexia, fever, weakness and/or fatigue in a patient in need thereof. In preferred embodiments, the anti- IL-6 antibodies will be humanized and/or will be aglycosylated. Also, in preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level. In another preferred embodiment, the patient's survivability or quality of life will preferably be improved.
