A burn treatment system utilizing a sprayer having smart moisture and temperature control. The burn treatment system comprises a smart moisture and temperature control console (1), a vacuum pump (2), moisture sensors, a fluid storage bottle (3), a suction tube (4), a fluid guiding dressing layer (5), an adhesive medical film (6), an atomizer (8), a temperature control device (80), a first temperature sensor and a spray tube (9). One end of the suction tube (4) communicates, directly or indirectly, with a 3-dimentional intercommunication structure of the fluid guiding dressing layer (5). The moisture sensor is arranged, directly or indirectly, in the fluid guiding dressing layer (5). The spray tube (9) communicates, directly or indirectly, with the three-dimensional intercommunication structure of the fluid guiding dressing layer (5). The first temperature sensor is arranged, directly or indirectly, in the fluid guiding dressing layer (5). The moisture sensor and the first temperature sensor feed back, accordi