부산대학교 산학협력단;PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION
发明人:
PARK, Bum-Joon,박범준,JUNG, Yun Jin,정연진
申请号：
KRKR2017/009766
公开号：
WO2018/048195A1
申请日:
2017.09.06
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
The present invention relates to a composition for prevention or treatment of intractable cancer containing quinacrine as an active ingredient. According to the present invention, since quinacrine inhibits the survival rate of cancer cells, increases the apoptosis of cancer cells, and is especially sensitive to aggressive cancer cells, the composition containing quinacrine as an active ingredient may be useful as a pharmaceutical composition for preventing or treating intractable cancer including recurrent cancer, p53-deficient cancer, p53-inactive cancer and terminal cancer, and a health food composition for preventing or ameliorating intractable cancer.L'invention concerne une composition pharmaceutique destinée à la prévention et au traitement d'un cancer réfractaire qui contient de la quinacrine en tant que principe actif. Selon la présente invention, puisque la quinacrine inhibe le taux de survie de cellules cancéreuses, augmente l'apoptose de cellules cancéreuses, et est particulièrement sensible aux cellules cancéreuses agressives, la composition contenant de la quinacrine en tant que principe actif peut être utile en tant que composition pharmaceutique pour la prévention ou le traitement d'un cancer réfractaire comprenant un cancer récurrent, un cancer à p53 déficient, un cancer à p53 inactif et un cancer terminal, et en tant que composition d'aliments naturels pour la prévention ou l'amélioration d'un cancer réfractaire.본 발명은 퀴나크린(Quinacrine)을 유효성분으로 함유하는 난치성 암 예방 또는 치료용 조성물에 관한 것으로, 본 발명에 따르면, 퀴나크린(Quinacrine)은 암세포의 생존율을 억제하고 암세포의 세포사멸을 증가시키며, 특히 침략적 암(aggressive cancer) 세포에서 민감성을 가지므로, 상기 퀴나크린을 유효성분으로 함유하는 조성물은 재발성 암, p53 결핍 암, p53 불활성 암 및 말기 암을 포함하는 난치성 암 예방 또는 치료용 약학 조성물, 및 난치성 암 예방 또는 개선용 건강식품 조성물로 유용하게 활용될 수 있다.
