GAUFRETEAU, Delphine,HILPERT, Hans,HUMM, Roland,KOLCZEWSKI, Sabine,MUSER, Thorsten,PLANCHER, Jean-Marc,STOLL, Theodor
申请号：
EPEP2016/076472
公开号：
WO2017/076931A1
申请日:
2016.11.03
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
The present invention is concerned with indolin-2-one derivatives of general formula (I) wherein A is phenyl or a six membered heteroaryl group, containing one or two N atoms, selected from or the oxygen atom may form together with two neighboring carbon atoms from the group A an additional fused ring, selected from or； R1 is hydrogen, lower alkyl, lower alkyl substitututed by halogen or oxetanyl； R2 is hydrogen, lower alkyl lower alkoxy, halogen or cycloalkyl； the dotted line is nothing or may be –CH2-； as well as with a pharmaceutically acceptable salt thereof, with a racemic mixture, or with its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. The compounds may be used in the treatment of CNS diseases related to positive (psychosis) and negative symptoms of schizophrenia, substance abuse, alcohol and drug addiction, obsessive- compulsive disorders, cognitive impairment, bipolar disorders, mood disorders, major depression, treatment resistant depression, anxiety disorders, Alzheimer's disease, autism, Parkinson's disease, chronic pain, borderline personality disorder, neurodegenerative disease, sleep disturbances, chronic fatigue syndrome, stiffness, inflammatory disease, asthma, Huntington's disease, ADHD, amyotrophic lateral sclerosis, effects in arthritis, autoimmune disease, viral and fungal infections, cardiovascular diseases, ophthalmology and inflammatory retinal diseases and balance problems, epilepsy and neurodevelopmental disorders with co morbid epilepsy.La présente invention concerne des dérivés indolin-2-one de formule générale (I) dans laquelle A représente un phényle ou un groupe hétéroaryle à six chaînons, contenant un ou deux atomes N, choisi parmi ou l'atome d'oxygène peut former, conjointement avec les deux atomes de carbone adjacents du groupe A, un cycle condensé supplémentaire choisi parmi ou ； R1 représente un hydrogène, un alkyle inférieur, un alkyle inférieur substitué par un halogène ou un oxétanyle ； R2 représe
