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Organic Bromofenac Salts and a Method for Their Preparation Containing Their Composition and Their Use
专利权人:
ЛТД. (CN);ШЭНЬЯН СИНЦИ ФАРМАСЬЮТИКАЛ КО.
发明人:
ЛЮ Цзидун (CN),ЯН Юйчун (CN),ВАН Цзюлян (CN),ТАН Хай (CN)
申请号:
RU2013132469/04
公开号:
RU2013132469A
申请日:
2011.12.13
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. An organic salt of bromphenac, which has the structure represented by the following formula I: I in which A is an organic base; preferably means a nitrogen-containing organic base. The organic bromfenac salt according to claim 1, which is the diethylamine salt of bromfenac or the tromethamol salt of bromfenac, i.e. has the structure represented by the following formula II or formula III: 3. A method for producing an organic salt of bromphenac according to claim 1 or 2, comprising the following steps: 1) dissolving bromphenac in an organic solvent, heating to dissolve, then adding an organic base in an equimolar amount, stirring until completion of the reaction; 2) concentrating and evaporating the solution of the reaction mixture to dryness to obtain a light yellow or orange-yellow solid; 3) recrystallization of the solid obtained in stage 2), to obtain an organic salt of bromfenac. 4. The method of claim 3, wherein said organic solvent in step 1) is one or more selected from the group consisting of methanol, ethanol, acetone, n-butanol and toluene, preferably acetone; and said organic base is a nitrogen-containing organic base, preferably diethylamine or trometamol. 5. The method of claim 3, wherein the temperature at which the heating is carried out in step 1) is 25-80 ° C; preferably equal to 45-65 ° C; more preferably 55 ° C. 6. The method of claim 3, wherein the duration of the stirring and reaction in step 1) is 0.5-2 hours; preferably equal to 1 h. 7. The method of claim 3, wherein the recrystallization in step 3) is carried out at a temperature1. Органическая соль бромфенака, которая имеет структуру, представленную приведенной ниже формулой I:Iв которой A означает органическое основание; предпочтительно означает азотсодержащее органическое основание.2. Органическая соль бромфенака по п. 1, которая является диэтиламиновой солью бромфенака или трометамоловой солью бромфенака, т.е. обладает структурой, представленной приведенной ниже формулой II или формулой
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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