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CRYSTAL PEPTIDE EPOXYKETONE IMMUNOPROTEASOMY INHIBITOR
专利权人:
ОНИКС ТЕРАПЬЮТИКС; ИНК. (US)
发明人:
ПХИАСИВОНГСА Пасит (US)
申请号:
RU2012147246/04
公开号:
RU2012147246A
申请日:
2011.04.06
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of obtaining a crystalline compound of formula (II) comprising (i) preparing a solution of a compound of formula (II) in an organic solvent; (ii) bringing the solution into a state of a supersaturated solution in order to cause the formation of crystals; and (iii) isolation of crystals. 2. The method according to claim 1, wherein the organic solvent is selected from acetonitrile, acetone, diethyl ether, diisopropyl ether, ethyl acetate, heptanes, isopropyl acetate, methanol, methyl tert-butyl ether, tetrahydrofuran, toluene, or any combination thereof. The method of claim 2, wherein the organic solvent is selected from toluene, methyl tert-butyl ether, heptanes, or combinations thereof. The method according to claim 1, wherein bringing the solution into a state of a supersaturated solution involves adding an anti-solvent, leaving the solution to cool, reducing the volume of the solution, or any combination thereof. The method according to claim 4, wherein bringing the solution into a state of a supersaturated solution involves cooling the solution to room temperature and reducing the volume of the solution. The method of claim 1, further comprising washing the crystals. The method of claim 6, wherein the washing comprises washing with a liquid selected from an anti-solvent, acetonitrile, acetone, diethyl ether, diisopropyl ether, ethanol, ethyl acetate, heptanes, isopropyl acetate, methanol, methyl tert-butyl ether, tetrahydrofuran, toluene, or any combination thereof , or combinations thereof. 8. The method of claim 7, wherein the washing comprises washing with a combination of toluene and methyl tert-butyl ether. The method of claim 7, wherein the washing comprises washing with toluene. The method according to claim 1, where the selection of crystals includes filtering the crystal�1. Способ получения кристаллического соединения формулы (II)включающий (i) приготовление раствора соединения формулы (II) в органическом растворителе; (ii) приведение раствор
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中国工程科技知识中心
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http://www.ckcest.cn/home/
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