CHANG, EDCON,NOTZ, WOLFGANG REINHARD LUDWIG,WALLACE, MICHAEL B.
申请号：
PE0000132015
公开号：
PE07542015A1
申请日:
2013.07.08
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
The Invention relates to compounds of Formula 1, and one of its pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 defined in memory.The present Disclosure also relates to materials and Methods for preparing compounds of Formula 1, to pharmaceutical compositions containing them and their use for treating immune disorders, cardiovascular diseases, cancer and other disorders, diseases and conditions Associated with the p13kdelta.Preferred compounds are: (S) 5 - Chloro - N4 - (1 - (1 - methyl - 4 - (1 - methyl - 5 - 1H pyrazole - yl) - 1H pyrrolo [3,2-b] pyridin - 5 - (IL) ethyl) - 2, 4 - diamine (S) - 2, 4 - diamino - 6 - ((1 - (1 - methyl - 4 - (1 - methyl - 5 - 1H pyrazole - yl) - 1H pyrrolo [3,2-b] pyridin - 5 - il) ethyl) amino) - 5 - carbonitrilo pyrimidine (S) - 2 - amino - 4 - methyl - 6 - ((1 - (1 Methyl 6 - (1 - methyl - 5 - 1H pyrazole - yl) - 1H pyrrolo [3,2 - B] pyridin - 5 - il) ethyl) amino) - 5 - carbonitrilo pyrimidine among othersLa invencion se refiere a los compuestos de la Formula 1, y una de sus sales farmaceuticamente aceptables, donde R1, R2, R3, R4, R5, R6, R7, R8, R9 y R10 se definen en la memoria. La presente revelacion tambien se refiere a los materiales y metodos para preparar compuestos de la Formula 1, a composiciones farmaceuticas que los contienen y a su empleo para tratar trastornos inmunologicos, enfermedades cardiovasculares, cancer y otros trastornos, enfermedades y afecciones que se asocian con la P13Kdelta. Son compuestos preferidos: (S)5-Cloro-N4-(1-(1-metil-6-(1-metil-1H-pirazol-5-il) -1H-pirrolo[3,2-b]piridin-5-il)etil)pirimidina-2 ,4-diamina (S)-2 ,4-Diamino-6-((1-(1-metil-6-(1-metil-1H-pirazol-5-il)-1H-pirrolo[3,2-b]piridin-5-il)etil)amino)pirimidina-5-carbonitrilo (S)-2-Amino-4-metil-6-((1-(1-metil-6-(1-metil-1H-pirazol-5-il)-1H-pirrolo[3 ,2-b]piridin-5-il)etil)amino)pirimidina-5-carbonitrilo entre otros
