BARBAY, KENT,EDWARDS, JAMES P.,KREUTTER, KEVIN D.,KUMMER, DAVID A.,MAHAROOF, UMAR,NISHIMURA, RACHEL,URBANSKI, MAUD,VENKATESAN, HARIHARAN,WANG, AIHUA,WOLIN, RONALD L.,WOODS, CRAIG R.,FOURIE, ANNE,XUE,
申请号：
PE0004922015
公开号：
PE12032015A1
申请日:
2013.10.15
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
The Invention relates to compounds of the formula I wherein: R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the specification. The Invention also includes a method for treating or improving a Syndrome, disorder or disease, such as rheumatoid arthritis or psoriasis.Also referred to a method to modulate the activity of ROR gamma t in a Mammal through the Administration of a therapeutically effective amount of at least one Compound of claim 1.Preferred compounds are (2,4 - Dichloro - 3 - (3-fluorophenyl) - 8 - metilquinolin IL - 6 - (1 - methyl) - 1H imidazole - 5 - (IL) - 6 - (trifluoromethyl) pyridin-3-yl) methanol (2,4 - Dichloro - 3 - (4-fluorophenyl metilquinolin) - 8 - il - 6 - (1 - methyl) - 1H imidazole (IL - 5 - (trifluoromethyl) 6) pyridin-3-yl) methanol, among othersLa invencion comprende compuestos de la Formula l en donde: R1, R2, R3, R4, R5, R6, R7, R8 y R9 son tal como se definieron en la especificacion. La invencion comprende, ademas, un metodo para tratar o mejorar un sindrome, trastorno o enfermedad, tales como artritis reumatoide o soriasis.Referida tambien a un metodo para modular la actividad de ROR-gamma-t en un mamifero por medio de la administracion de una cantidad terapeuticamente eficaz de por lo menos un compuesto de la reivindicacion 1. Los compuestos preferidos son: (2,4-dicloro-3-(3-fluorofenil)-8-metilquinolin-6-il)(1-metil-1H-imidazol-5-il)(6-(trifluorometil)piridin-3-il)metanol (2,4-dicloro-3-(4-fluorofenil)-8-metilquinolin-6-il)(1-metil-1H-imidazol-5-il)(6 (trifluorometil)piridin-3-il)metanol, entre otros
