PROBLEM TO BE SOLVED: To provide a pharmaceutical composition improved in preventive and/or therapeutic effects on a dermatitis with eczema and urticaria and a rhinitis with sneeze and nasal liquid by having reinforced an antiallergic action of a fexofenadine hydrochloride.SOLUTION: The antihistamine composition contains the fexofenadine hydrochloride, vitamin B2 and/or vitamin C.