USE OF BACTERIA, BACTERIAL PRODUCTS, AND OTHER IMMUNOREGULATORY ENTITIES IN COMBINATION WITH ANTI-CTLA-4 AND/OR ANTI-PD-1 ANTIBODIES TO TREAT SOLID TUMOR MALIGNANCIES
BIOMED VALLEY DISCOVERIES, INC.;THE JOHNS HOPKINS UNIVERSITY
发明人:
SHIBIN ZHOU,BERT VOGELSTEIN,KENNETH KINZLER,KIBEM KIM,SAURABH SAHA
申请号：
US15301163
公开号：
US20170020931A1
申请日:
2015.03.31
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The presently disclosed subject matter provides methods and kits for treating solid tumors in a subject by using a combination of anti-CTLA-4 and/or anti-PD-1 antibodies with at least one member of the group consisting of a bacterium, bacterial product, and an immunoregulatory entity. In particular embodiments, the bacteria are toxin-depleted, anaerobic bacteria, such as Clostridium novyi-NT.
