Use of bacteria, bacterial products, and other immunoregulatory entities in combination with anti-CTLA-4 and/or anti-PD-1 antibodies to treat solid tumor malignancies

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专利权人:

The Johns Hopkins University

发明人:

Zhou, Shibin,Vogelstein, Bert,Kinzler, Kenneth,Kim, Kibem

申请号：

AU2015240884

公开号：

AU2015240884A1

申请日:

2015.03.31

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

The presently disclosed subject matter provides methods and kits for treating solid tumors in a subject by using a combination of anti-CTLA-4 and/or anti-PD-1 antibodies with at least one member of the group consisting of a bacterium, bacterial product, and an immunoregulatory entity. In particular embodiments, the bacteria are toxin-depleted, anaerobic bacteria, such as Clostridium novyi-NT.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/