USE OF BACTERIA, BACTERIAL PRODUCTS, AND OTHER IMMUNOREGULATORY ENTITIES IN COMBINATION WITH ANTI-CTLA-4 AND/OR ANTI-PD-1 ANTIBODIES TO TREAT SOLID TUMOR MALIGNANCIES

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专利权人:

The Johns Hopkins University

发明人:

ZHOU, Shibin,VOGELSTEIN, Bert,KINZLER, Kenneth,KIM, Kibem,SAHA, Saurabh

申请号：

EP15773992

公开号：

EP3125938A4

申请日:

2015.03.31

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

The presently disclosed subject matter provides methods and kits for treating solid tumors in a subject by using a combination of anti-CTLA-4 and/or anti-PD-1 antibodies with at least one member of the group consisting of a bacterium, bacterial product, and an immunoregulatory entity. In particular embodiments, the bacteria are toxin-depleted, anaerobic bacteria, such as Clostridium novyi-NT.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/