The present disclosure relates to methods of treating or preventing a proliferative disease in a patient in need thereof by orally administering a therapeutically effective amount of a phosphatidylinositol 3-kinase inhibitor compound or a pharmaceutically acceptable salt thereof once-per-day either on a continuous daily schedule or an intermittent schedule at about zero to about three hours prior to sleep； the use of said compound or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for treating or preventing a proliferative disease administered in accordance with said dosage regimen； a therapeutic regimen comprising administration of said compound or a pharmaceutically acceptable salt thereof in accordance with said dosage regimen； and related pharmaceutical compositions and packages thereof.本發明係關於治療或預防有需要患者之增生性疾病的方法，其係藉由以連續性日常時程或間歇性時程每日一次地在睡前約零至約三小時經口投與治療有效量之磷脂醯肌醇3-激酶抑制劑化合物或其醫藥學上可接受之鹽；該化合物或其醫藥學上可接受之鹽的用途，其用於製造根據該劑量療法投與之用於治療或預防增生性疾病的藥物；一種治療療法，其包含根據該劑量療法投與該化合物或其醫藥學上可接受之鹽；及相關醫藥組合物及其包裝。
