SELS DE MALEATE D'UN INHIBITEUR DE KINASE B-RAF, FORMES CRISTALLINES, PROCEDES DE PREPARATION, ET LEURS UTILISATIONS

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专利权人:

LTD.;BEIGENE

发明人:

ZHANG, GUOLIANG,ZHOU, CHANGYOU

申请号：

CA2981746

公开号：

CA2981746A1

申请日:

2016.04.14

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

The invention relates to 5- ( ( (1R, 1aS, 6bR) -1- (6- (trifluoromethyl) -1H-benzo [d] imidazol-2-yl) -1a,6b-dihydro-1H-cyclopropa [b] benzofuran-5-yl) oxy) -3, 4-dihydro-1, 8-naphthyridin-2 (1H) -one (Compound 1) maleate salts, in particular the sesqui-maleate salt and its crystalline forms, methods of preparation, pharmaceutical compositions, and therapeutic uses for treatment of diseases or disorders mediated by BRAF or other kinases.

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