Maleate salts of a B-RAF kinase inhibitor, crystalline forms, methods of preparation, and uses therefore

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专利权人:

Ltd.;BeiGene

发明人:

Zhang, Guoliang,Zhou, Changyou

申请号：

AU2016248376

公开号：

AU2016248376A1

申请日:

2016.04.14

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

The invention relates to 5- ( ( (1R, 1aS, 6bR) -1- (6- (trifluoromethyl) -1H-benzo [d] imidazol-2-yl) -1a,6b-dihydro-1H-cyclopropa [b] benzofuran-5-yl) oxy) -3, 4-dihydro-1, 8-naphthyridin-2 (1H) -one (Compound 1) maleate salts, in particular the sesqui-maleate salt and its crystalline forms, methods of preparation, pharmaceutical compositions, and therapeutic uses for treatment of diseases or disorders mediated by BRAF or other kinases.

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中国工程科技知识中心

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