Maleate salts of a B-RAF kinase inhibitor, crystalline forms, methods of preparation, and uses therefore

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专利权人:

BeiGene; Ltd.

发明人:

Guoliang Zhang,Changyou Zhou

申请号：

US15565807

公开号：

US10351559B2

申请日:

2016.04.14

申请国别(地区):

US

年份:

2019

代理人:

摘要：

The invention relates to 5-(((1R,1aS,6bR)-1-(6-(trifluoromethyl)-1H-benzo [d] imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa [b] benzofuran-5-yl) oxy)-3,4-dihydro-1, 8-naphthyridin-2 (1H)-one (Compound 1) maleate salts, in particular the sesqui-maleate salt and its crystalline forms, methods of preparation, pharmaceutical compositions, and therapeutic uses for treatment of diseases or disorders mediated by BRAF or other kinases.

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