The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as ARM-HI"s function through orthogonal pathways, by inhibiting the gpl20-CD4 interaction, and by recruiting anti-DNP antibodies to gpl20 expressing cells, thereby preventing cell infection and spread of HIV. It has been shown that ARM-HI s bind to gpl20 and gp 120 expressing cells competitively with CD4, thereby decreasing viral infectivity as shown by an MT-2 cell assay, the binding leading to formation of a ternary complex by recruiting anti DNP antibodies to bind thereto the antibodies present in the ternary complex promoting the complement dependent destruction of the gpl20 expressing cells. Compounds and methods are described herein.
