SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR NEUROMELANIN-SENSITIVE MAGNETIC RESONANCE IMAGING AS A NON-INVASIVE PROXY MEASURE OF DOPAMINE FUNCTION IN THE HUMAN BRAIN
The Trustees of Columbia University in the City of New York;THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.
发明人:
GUILLERMO HORGA HERNANDEZ,CLIFFORD MILLS CASSIDY
申请号：
US17226375
公开号：
US20210228144A1
申请日:
2021.04.09
申请国别(地区):
US
年份:
2021
代理人:
摘要：
An exemplary system, method and computer-accessible medium for determining a dopamine function of a patient(s) can include, for example, receiving imaging information of a brain of the patient(s), determining a Neuromelanin (NM) concentration of the patient(s) based on the imaging information, and determining the dopamine function based on the NM concentration. The NM concentration can be determined using a voxel-wise analysis procedure. The voxel-wise analysis procedure can be used to determine a topographical pattern(s) within a substantia nigra (SN) of the brain of the patient(s). The topographical pattern(s) can include a pattern(s) of cell loss in the SN. The NM concentration can be based on a NM loss in the brain of the patient(s).
