ZHU Li (CN),ЧЖУ Ли (CN),XIAO Dengming (CN),СЯО Дэнмин (CN),HU Yuandong (CN),ХУ Юаньдун (CN),DAI Liguang (CN),ДАЙ Лигуан (CN),DUAN Xiaowei (CN),ДУАНЬ Сяовэй (CN),SUN Yinghui (CN),СУНЬ Инхуй (CN),PENG Y
申请号：
RU2017122824
公开号：
RU0002701206C2
申请日:
2015.12.15
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to a novel pyrrolopyrimidine compound of general formula (I), a stereoisomer thereof or a pharmaceutically acceptable salt thereof. In general formula (I)each of R1 and R2 is independently selected from a group consisting of H, halogen, cyano, C1-8alkyl, -NR7R8, -NH-C1-6alkylene-NR9R10, -NHCO-C1-6alkylene-NR9R10, -NH-C1-6alkylene-CO-NR9R10, -NHCO-C1-6alkylene-COO-C1-6alkyl, -NH-C3-6cycloalkylene-CO-NR9R10, -NH-C2-6alkenylene-CONR9R10, -NH-C1-6alkylene-cyano, -NHCO-NH-R11, -CONR12R13 and -CONH-C1-6alkylene-NR12R13, wherein C1-8alkyl is optionally substituted with hydroxyl, halogen, -NH2, -NH (C1-6alkyl), -N (C1-6alkyl)2, provided that R1 and R2 simultaneously are not H； each of R7 and R8 is independently selected from a group consisting of H, C1-6alkyl, C1-6alkylcarbonyl and C1-6alkylsulphonyl； or R7 and R8 together with atom N, to which they are bonded, form 5- or 6-member heterocyclyl, and said 5- or 6-member heterocyclyl contains atom N as a heteroatom and optionally substituted with oxo； each of R9 and R10 is independently selected from a group consisting of H, hydroxyl and C1-6alkyl； or R9 and R10 together with atom N, to which they are bonded, form 5- or 6-member heterocyclyl with 1-2 heteroatoms selected from N and O； R11 is selected from a group consisting of 5-member heteroaryl containing two N atoms and atom O as heteroatoms and optionally having substituent C1-4alkyl； each of R12 and R13 is independently selected from a group consisting of H and C1-6alkyl； R3 is selected from a group consisting of H and halogen； R4 is selected from a group consisting of cyano and -CONH2； and each of R5 and R6 is independently selected from a group consisting of H, hydroxyl and halogen.EFFECT: compounds can be used for treating a tumour caused by Janus kinase activity, such a disease can be lymphoma, leukaemia.19 cl, 7 tbl, 34 exИзобретение относится к новому пирролопиримидиновому соединению общей формулы (I), его стереоизомеру
