Moore, Stephen James,Nguyen, Margaret Thy Luu,Hostetter, Daniel R.,Vasiljeva, Olga
申请号：
AU2015210862
公开号：
AU2015210862A1
申请日:
2015.01.30
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator (uPA), to activatable antibodies and other larger molecules that include the cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator, and to methods of making and using these polypeptides that include a cleavable moiety that is a substrate for at least one protease selected from matriptase and uplasminogen activator in a variety of therapeutic, diagnostic and prophylactic indications.
