Stephen James Moore,Margaret Thy Luu Nguyen,Daniel R. Hostetter,Olga Vasiljeva
申请号：
US14610468
公开号：
US20150218217A1
申请日:
2015.01.30
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator (uPA), to activatable antibodies and other larger molecules that include the cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator, and to methods of making and using these polypeptides that include a cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator in a variety of therapeutic, diagnostic and prophylactic indications.
