Lipophilic oligonucleotide comprising a phosphate glycerol unit containing at least one aliphatic unsaturated carbon bond according to formula IwithOligonucleotide =an unmodified or modified nucleic acid of 2 - 1000 nucleotides in lengthR =a bond or a linker unitY =OH, SH or NHR3X and Z =independently O, S or NR3R3 =hydrogen or branched or unbranched and/or substituted or unsubstituted alkyl, aryl and/or alkyl aryl residue with 10 to 30 carbon atomsR1, R2 =branched or unbranched and/or substituted or unsubstituted alkyl, aryl and/or alkylaryl residue with 10 to 30 carbon atoms, with the provisio that at least one of the residues R1 or R2 comprises at least one aliphatic carbon-carbon double bondUse of lipophilic oligonucleotide according to Formula I for drug discovery or for transfection of cells.
