Composition for transduction of oligonucleotides active in gene silencing and its biological and therapeutic applications

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专利权人:

ポリプラス トランスフェクション エスアー

发明人:

ノイベルク パトリック,ボルカト ベルマン アンヌ ロール,ベア ジャン ポール,エルバッハー パトリック

申请号：

JP2009503686

公开号：

JP5270531B2

申请日:

2007.04.05

申请国别(地区):

JP

年份:

2013

代理人:

摘要：

The invention relates the compositions of transfection comprising an oligonucleotide active for RNA interference and an amphiphilic cationic molecule of formula (I) wherein - X is N-R 1 , S or 0, R 1 being a C1-C4 alkyl radical or an hydroxylated C3- C6 alkyl radical, - R 2 and R 3 , identical or different, represent H or a C1-C4 alkyl radical, or R 2 and R 3 are linked together to form a cycle or a heterocycle having 6 elements, - E is a C1-C5 alkyl spacer, - R 4 and R 5 , identical or different, represent saturated or unsaturated, linear or branched, C10-C36 hydrocarbon or fluorocarbon chains, optionally comprising C3-C6 cycloalkyle, - A - is a biocompatible anion. Use of said compositions as drugs.

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