Phenyl C-glucoside derivative having deoxyglucose structure, preparation method and use thereof农业专利-农业专业知识服务系统

发明人:: ジャオ，グイロン,ワン，ユーリー,リュウ，ビンニー,シエ，ヤーフェイ,リュウ，ユーチアン,リュウ，ポン,ウー，ジアン,ホウ，ジアジア,ウェイ，ウェイ,ドゥー，ウェン,シュー，ウェイレン,タン，リーダ,ゾウ，メイシアン,ジャオ, グイロン,ワン, ユーリー,リュウ, ビンニー,シエ, ヤーフェイ,リュウ, ユーチアン,リュウ, ポン,ウー, ジアン,ホウ, ジアジア,ウェイ, ウェイ,ドゥー, ウェン,シュー, ウェイレン,タン, リーダ,ゾウ, メイシアン

摘要：: The present invention provides a phenyl C-glucoside derivative containing a deoxyglucose structure as represented by formula I, preparation method thereof, a pharmaceutical composition comprising the same, and uses thereof in the preparation of medicaments for treating diabetes, wherein substituents R 1 -R 7 are as defined in the specification. The present invention also provides a method for synthesizing the phenyl C-glucoside derivative containing a deoxyglucose structure and an intermediate product. The method has advantages of being simple to manage and of low cost, which is suitable for large-scale industrial production. The present invention further provides a cocrystal of (1S)-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-1,6-dideoxy-D-glucose and L-proline, and preparation method and uses thereof.