APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.;BIFFONI, MAURO;PAPOIAN, RUBEN
发明人:
BIFFONI, MAURO,PAPOIAN, RUBEN
申请号：
WO1996EP05280
公开号：
WO9823748(A1)
申请日:
1996.11.29
申请国别(地区):
世界知识产权组织国际局
年份:
1998
代理人:
摘要：
A method to prevent graft rejection of transplanted cells, tissues or organs without general immunosuppression is described. The method employs a newly discovered protein, LAG-3. When allogeneic or xenogeneic cells are engineered to express LAG-3 on their surface and transplanted, immune destruction of the implanted cell, tissue or organ is prevented, while the host's immune system remains functional. A particular application of this method allows the preparation of a universal gene therapy host cell expressing LAG-3 on its surface for protection from graft rejection by a host's immune system.
