MATTHIAS HOFFMANN,ANDREAS SCHNAPP,GEORG DAHMANN,GERHARD SCHAENZLE,SANDRA HANDSCHUH,GUENTER LINZ,DENNIS FIEGEN,JASNA KLICIC,STEPHEN P. EAST,MICHAEL PHILIP MAZANETZ,JOHN ROBERT SCOTT,EDWARD WALKER
申请号：
MX2012008533
公开号：
MX2012008533A
申请日:
2011.01.21
申请国别(地区):
MX
年份:
2012
代理人:
摘要：
The invention relates to new substituted naphthyridines of formula (1), as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein R1 is selected from among -O-R3 or -NR3R4, R3 is C1-6-alkyl which is substituted by R5 and R6 R5 is selected from hydrogen, branched or linear C1-6-alkyl, C2-6-alkenyl, -C1-6-alkylen-O-C1-3-alkyl, C1-3-haloalkyl, R6 is ring X wherein n is either 0 or 1, and Formula (I) is a either a single or a double bond and wherein A, B, D and E are each independently from one another selected from CH2, CH, C, N, NH, O or S and wherein ring X is attached to the molecule either via position A, B, D or E, wherein said ring X may optionally be further substituted by one, two or three residues each selected individually from the group consisting of -oxo, hydroxy, -C1-3-alkyl, -C1-3-haloalkyl, -O-C1-3-alkyl, -C1-3-alkanol and halogen, and wherein R4, R2, R7, R8, R9, R10, R11 and Q may have the meanings as given in claim 1, as well as pharmaceutical compositions containing these compounds.La invención se refiere a nuevas naftiridinas sustituidas de fórmula 1, como también a sus sales, diastereómeros, enantiómeros, racematos, hidratos o solvatos farmacológicamente aceptables, (ver fórmula) en la que R1 se selecciona entre -O-R3 o -NR3R4, R3 es alquilo C1-6 que sustituido con R5 y R6, R5 se selecciona entre hidrógeno, alquilo C1-6 lineal o ramificado, alquenilo C2-6, -alquilen C1-6 -O-alquilo C1-3, haloalquilo C1-3, R6 es un anillo X (ver fórmula) donde n es 0 ó 1, y donde es o bien un enlace sencillo o un doble enlace y donde A, B, D y E se seleccionan cada uno independientemente unos de otros de CH2, CH, C, N, NH, O o S y donde el anillo X está unido a la molécula mediante la posición A, B, D o E, donde dicho anillo X puede estar opcionalmente sustituido con uno, dos o tres
