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imidazopyrazines
专利权人:
F. Hoffmann-La Roche AG
发明人:
LUK, Kin-Chun Thomas,SOTH, Michael
申请号:
ES12709607
公开号:
ES2590928T3
申请日:
2012.03.14
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
Compound of formula I: ** Formula ** in which: X is selected from CH or N, R1 and R2 are independently selected from the group consisting of: (a) H, (b) C1-4 alkyl, (c) C1-4 alkyl substituted with up to 3 groups selected from cycloalkyl, heterocycle, OR5, NR5R610, SO2R7 or CN, (d) heterocycle, (e) heterocycle substituted with up to three groups selected from C1-4 alkyl, OR8 , NR8R9 or CN, (f) cycloalkyl and (g) cycloalkyl substituted with up to three groups selected from C1-4 alkyl, OR8, NR8R9 or CN, or alternatively, NR1R2 together may be a heterocycle that may optionally be substituted with C1- alkyl 4, R3 is selected from the group consisting of: (a) C1-6 alkyl, (b) C1-6 alkyl substituted with up to 3 groups selected from aryl, aryl substituted with Cl, F, CH3, or CF3, heteroaryl, cycloalkyl, heterocycle, OH, OCH3, NR8R9 and CN, (c) aryl, (d) aryl substituted with Cl, F, C1-4 alkyl or CF3, (e) heteroaryl, (f ) cycloalkyl optionally substituted with OR5, and (g) heterocycle, R4, R8 and R9 are independently selected from the group consisting of: (a) H, and (b) C1-4 alkyl, or alternatively, NR3R4 together may be a heterocycle that may optionally be substituted with C1-4 alkyl, R5 and R6 are independently selected from the group consisting of: (a) H, and (b) C1-4 alkyl and R7 is selected from group (a) C1-4 alkyl and (b) cycloalkyl, or a pharmaceutically acceptable salt thereof.Compuesto de fórmula I:**Fórmula** en la que: X se selecciona de entre CH o N, R1 y R2 se seleccionan independientemente de entre el grupo que consiste de: (a) H, (b) alquilo C1-4, (c) alquilo C1-4 sustituido con hasta 3 grupos seleccionados de entre cicloalquilo, heterociclo, OR5, NR5R610 , SO2R7 o CN, (d) heterociclo, (e) heterociclo sustituido con hasta tres grupos seleccionados de entre alquilo C1-4, OR8, NR8R9 o CN, (f) cicloalquilo y (g) cicloalquilo sustituido con hasta tres grupos seleccionados de entre alquilo C1-4, OR8, NR8R9 o CN, o alternativamente, NR1R2 conjuntamente puede ser un
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