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Hydrogen trifluoride as a rorgt modulator
专利权人:
JANSSEN PHARMACEUTICA N.V.
发明人:
申请号:
ARP150103522
公开号:
AR102480A1
申请日:
2015.10.30
申请国别(地区):
AR
年份:
2017
代理人:
摘要:
Claim 1: a compound of formula (1) wherein: X is n or CH, cr u00b9 a u00b9 is c u2081 u208b u2082; rent; rent c u2081 u208b u2084 a-squared is ciclobutilo or, where that is c u2081 u208b u2084 substituted alkyl, optionally with och u2083 or three Fluorine Atoms; or a u00b9 a-squared and considered together with its NITROGEN together to form a Ring selected from the group consisting azetidinilo, piperidinilo, pirrolidinilo,A rest of formula (2) and a remainder formula (3); where that ring is substituted, optionally with three substituents selected irrespective of the group consisting of F, cf u2083, ch u2083, - cn and ch u2082oh; r u00b9 is CL, C (ch u2083) u2083, ch u2082ch u2083, ocf u2083, cf u2083, och ( u2082, chf u2082, ch u2083) Ochf u2082, och u2083, F, ch u2083 or R u00b2 is H, CN;F or cl; or r u00b9 and R u00b2 may be considered together with their phenyl group together to form a naftalenilo or quinolinilo; r u00b3 is cf u2083 or ch u2082ch u2083; A u00b3 is h; a u2074 c u2081 u208b u2085 is H, alkyl group, or a compound of the formula (4), in which the c u2081 u208b u2085 is substituted alkyl, optionally With one to two substituents selected regardless of COOH, conh u2082,Cn and Oh; or A u00b3 and a u2074 may be considered together with their nitrogen together to form a Ring selected from the group consisting of formulas in the Group (5); and pharmaceutically acceptable salts thereof.Reivindicación 1: Un compuesto de fórmula (1) en donde: X es CH, CR¹ o N; A¹ es alquilo C₁₋₂; A² es ciclobutilo o alquilo C₁₋₄, en donde ese alquilo C₁₋₄ está sustituido, opcionalmente, con OCH₃ o hasta tres átomos de flúor; o A¹ y A² se consideran conjuntamente con su nitrógeno unido para formar un anillo seleccionado del grupo que consiste en azetidinilo, piperidinilo, pirrolidinilo, un resto de fórmula (2) y un resto de fórmula (3); en donde ese anillo está sustituido, opcionalmente, con hasta tres sustituyentes seleccionados independientemente del grupo que consiste en F,
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