It is a kind of to allow the amount of succinate dehydrogenase inhibitors that effective reason microbiological materials that are located in be needed to be substantially reduced to enhance the activity of succinate dehydrogenase containing succinate dehydrogenase inhibitors and the synergist having found. The composition can be used as the paint and coating of additive, protect crops, seed, wallboard, metal working fluids, and timber is from mold, fungi and other microorganisms.