THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
MACIAG, ANNA E.,KEEFER, LARRY K.,SAAVEDRA, JOSEPH E.,JI, XINHUA,KUMARI, VANDANA
申请号：
CA2852682
公开号：
CA2852682C
申请日:
2012.10.18
申请国别(地区):
CA
年份:
2020
代理人:
摘要：
Disclosed are hybrid compounds that release both nitric oxide and a moietythat inhibits poly (ADP-ribose) polymerase(PARP), e.g., a compound or a pharmaceutically acceptable salt thereof offormula (I), wherein R1-4 and m-p are as describedherein. Also disclosed are pharmaceutical compositions and methods of useincluding treating cancer and enhancing the chemotherapeutictreatment of chemotherapeutic agents and high energy radiation.
