Calvert, Alan Hilary,Hostomsky, Zdenek,Newell, David Richard,Plummer, Elizabeth Ruth,Steinfeldt, Heidi Marie,Thomas, Huw David,Stratford, Ian J.,Klamerus, Karen J.,Williams, Kaye Janine,Dewji, Mohamed
申请号：
AU2011253816
公开号：
AU2011253816A1
申请日:
2011.12.02
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2011253816A120120112.pdf#####-THERAPEUTIC COMBINATIONS COMPRISING POLY(ADP-RIBOSE) POLYMERASES INHIBITOR Abstract The invention generally relates to use of 8-fluoro-2-{4-[(methylamino)methyl]pheny)}-1, 5 3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one represented by Formula (1) as a chemosensitizer that enhances the efficacy of cytotoxic drugs or radiotherapy. The invention also relates to pharmaceutical combinations of 8-fluoro-2-{4-[(methylamino)methylpheny)}-1, 3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, or a pharmaceutically acceptable salt thereof and at least one additional therapeutic agent, kits containing such combinations and methods of 10 using such combinations to treat subjects suffering from diseases such as cancer.
