Lisa M. Cechetto;David S. F. Young;Helen P. Findlay;Susan E. Hahn;Fortunata McConkey;Maximiliano Vasquez
发明人:
David S. F. Young,Helen P. Findlay,Susan E. Hahn,Lisa M. Cechetto,Fortunata McConkey,Maximiliano Vasquez
申请号：
US13310917
公开号：
US20120201751A1
申请日:
2011.12.05
申请国别(地区):
US
年份:
2012
代理人:
摘要：
This invention relates to the staging, diagnosis and treatment of cancerous diseases (both primary tumors and tumor metastases), particularly to the mediation of cytotoxicity of tumor cells； and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more CDMAB/chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays, which utilize the CDMAB of the instant invention. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, cytokines, interferons, target or reporter moieties and hematogenous cells.
