Immunomedics, Inc.;Center for Molecular Medicine and Immunology
发明人:
Burton, Jack D.,Stein, Rhona,Goldenberg, David M.
申请号：
AU2011203890
公开号：
AU2011203890A1
申请日:
2011.01.11
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Disclosed herein are methods and compositions comprising interferon-γ (IFN-γ) and anti-CD74 or anti-HLA-DR antibodies. In preferred embodiments, the IFN-γ increases the expression of CD74 and/or HLA-DR in target cells and increases the sensitivity of the cells to the cytotoxic effects of the anti-CD74 or anti-HLA-DR antibodies. The compositions and methods are of use to treat diseases involving CD74 and/or HLA-DR cells, such as cancer cells, autoimmune disease cells or immune dysfunction disease cells.
