BENTLEY, MICHAEL, D. MD,VIEGAS, TACEY, X. TX,GOODIN, RICHARD, R. RR,LIN CHENG L,XUAN ZHAO X,‧本特利,‧維加斯,‧古丁,‧陳,‧趙
申请号:
HK11100783.8
公开号:
HK1146645B
申请日:
2011.01.26
申请国别(地区):
HK
年份:
2015
代理人:
摘要:
The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water-soluble oligomer.