In a delayed release formulation comprising a core containing a drug and a delayed release coating for providing intestinal release, release of the drug in the colon is accelerated by including an isolation layer between the core and the delayed release coating. The delayed release coating comprises an inner layer and an outer layer. The outer layer comprises a pH dependently soluble polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a soluble non-ionic polymer which is soluble in intestinal fluid or gastrointestinal fluid, and at least one additive selected from a buffer agent and a base.一種緩釋藥物配方包含一含有藥物的核心以及一用於提供於腸內釋放的緩釋塗層，藉由在該核心與該緩釋塗層之間包括一隔離層，可使該藥物在結腸內的釋放加速。該緩釋塗層包含一內層以及一外層。該外層包含一具有pH臨界值為約5或以上的pH依賴性可溶性聚合物材料。該內層包含一可溶於腸液或胃腸液的可溶性非離子聚合物、及至少一選自一緩衝劑及一鹼的添加劑。
