VARUM, FELIPE JOSÉ OLIVEIRA,BRAVO GONZÁLEZ, ROBERTO CARLOS,BUSER, THOMAS,BASIT, ABDUL WASEH,FREIRE, ANA CRISTINA
申请号：
SG11201600501U
公开号：
SG11201600501UA
申请日:
2013.10.29
申请国别(地区):
SG
年份:
2016
代理人:
摘要：
In a delayed release formulation comprising a core containing a drug and a delayed release coating for providing intestinal release, release of the drug in the colon is accelerated by including an isolation layer between the core and the delayed release coating. The delayed release coating comprises an inner layer and an outer layer. The outer layer comprises a pH dependently soluble polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises (i) a soluble non-ionic polymer which is soluble in intestinal fluid or gastrointestinal fluid, and (ii) at least one additive selected from a buffer agent and a base.
