VARUM, Felipe Jos Oliveira,BRAVO GONZLEZ, Roberto Carlos,BUSER, Thomas,BASIT, Abdul Waseh,FREIRE, Ana Cristina
申请号：
HK16110696.8
公开号：
HK1222547A
申请日:
2016.09.08
申请国别(地区):
HK
年份:
2017
代理人:
摘要：
In a delayed release formulation comprising a core containing a drug and a delayed release coating for providing intestinal release, release of the drug in the colon is accelerated by including an isolation layer between the core and the delayed release coating. The delayed release coating comprises an inner layer and an outer layer. The outer layer comprises a pH dependently soluble polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises (i) a soluble non-ionic polymer which is soluble in intestinal fluid or gastrointestinal fluid, and (ii) at least one additive selected from a buffer agent and a base.
