Problem of the present invention is that expense is to effect height, the property of prescription agent, in large-scale production, the suitable substantially uniform liposome used in clinic can be used to be produced method. It is about 1: 5~1:8 to the mass ratio of lipid that [solution] lipide component and enclosed therapeutic agent, which have liposome therapeutic agent, the molar ratio of lipid components DSPC, DSPG, cholesterol is compression ratio about contained by 3:1: 2, is lower than 0.70ml/g liposomes. In Fig. 4