KOBAYASHI, MAMORU,TOMIYAMA, YOSHITAKA,KOBAYASHI, KUMI
申请号：
CA2628476
公开号：
CA2628476C
申请日:
2006.11.22
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention provides pharmaceutical compositions useful for relieving pain caused by ureteral calculi, facilitating exclusion of ureteral calculi or the like. That is, the present invention provides a pharmaceutical composition for the treatment of ureteral lithiasis, which comprises as an active ingredient an indoline derivative represented by the following general formula (I) or a salt thereof. In the formula, R represents saturated or unsaturated aliphatic acyl which may have a substituent ； hydroxyalkyl ； aliphatic acyloxyalkyl ； lower alkyl which has as a substituent lower alkoxy, carboxy, lower alkoxycarbonyl, aryl-substituted lower alkoxycarbonyl, carbamoyl, mono or di( lower alkyl) -substituted carbamoyl or cyano； optionally substituted aromatic acyl ； furoyl or pyridylcarbonyl； R1 represents cyano or carbamoyl； and R2 represents lower alkyl which may have as a substituent halogen, cyano or aryl. (see formula I)
